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A combination of supersizing and unrealistic beauty standards has pressured most of us to question the way in which we eat and look, and the dieting industry has been more than pleased to offer us 1000's of weight-loss solutions every year. The exception to the rule is the DOT1 household, members of which methylate K79 within the globular area of histone H3 and which are structurally not associated to SET-domain proteins four - 6 Latest work means that SET-domain-containing proteins methylate just a few proteins along with histones (see later)